Saturday, April 23, 2011

Latest News on LDN, a Possible Treatment for GWI, IBS, FM and more

The following were posted to the Low Dose Naltrexone website, at

Special thanks to tireless GWI and MS advocate Nancy Rekowski for submitting this!

Successful Crohn’s Disease Trial Results Published. Jill P. Smith, MD, Professor of Gastroenterology at Pennsylvania State University's College of Medicine, and her colleagues, have published the results of their Phase II study of 40 adults with Crohn’s disease, “Therapy with the Opioid Antagonist Naltrexone Promotes Mucosal Healing in Active Crohn’s Disease: A Randomized Placebo-Controlled Trial”, in the online journal Digestive Diseases and Sciences, March 8, 2011.

The 4.5mg daily dose of naltrexone proved to have very positive results, with significant improvements in the Crohn’s Disease Activity Index scores and with substantial healing demonstrated by endoscopy. (See Clinical Trials for LDN / Recently Published.)


Several Major Clinical Trials of LDN Await Publication. Three important clinical trials of LDN have each recently completed their planned studies and are now either undergoing final statistical analysis or are awaiting peer-review medical journal publication. Until that final step is achieved, we are proscribed from reporting any significant data results. However, we are pleased to observe that various useful outcomes will be reported by all three. The trials involved:

  • LDN effects in HIV/AIDS in Mali, Africa
  • LDN for fibromyalgia — a randomized, double-blind study at Stanford University
  • LDN for Crohn’s disease — a Phase II, randomized placebo-controlled double-blinded study at Hershey Medical Center, Penn State College of Medicine


Anonymous said...

I tried LDN for six months. Had to order it from Skips Pharmacy in Florida. Anyway, it didn't improve my muscle pain and fatigue, but it did cause a decrease in libido. It's possible some folks tolerate it better than I did. Just my two cents.

Dave Winnett
Captain, USMC (Ret.)
100% Disabled Gulf War Veteran

Anonymous said...

I have CFS/FIBRO/IBS, LDN has helped my IBS a lot, and the ostero knee pain, or its knee pain from CFS, no one really knows. I can walk half the day now as before COULDNT walk with out lots of pain meds and rests. I no longer take daily half dozen or more motrin or vicodin or flexeral, only 1.5 of my LDN at bed time only! EVEN MY MOOD has gotten better, endorphins, what can I say, they are a bit of happiness. THEY are natures pain killers and natures anti inflammatories!! Endorphins are released in your systems while you sleep while on LDN.. TILL THERE IS A CURE, there is LDN!! LOVE'N it!

Anonymous said...

Come up with the right treatment. There are several medications you can also choose.

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