Wednesday, February 3, 2010

Metabolic Syndrome associated with Chronic Fatigue Syndrome, study shows

Written by Anthony Hardie, 91outcomes

( -- A new study, published January 25 in the medical journal Metabolism, found that metabolic syndrome was found more frequently in people suffering from Chronic Fatigue Syndrome/Myalgic Encephelopathy (CFS/ME) than people who did not have the disease.

In turn, metabolic syndrome further worsened the fatigue symptoms.

According to Google Health:

Metabolic syndrome is a name for a group of symptoms that occur together and promote the development of coronary artery disease, stroke, and type 2 diabetes.

Alone, the symptoms can cause medical issues. Combined, they can present severe health problems.

Symptoms include:

  • Extra weight around your waist (central or abdominal obesity)
  • High blood pressure
  • High triglycerides (a type of blood fat)
  • Insulin resistance
  • Low HDL ("good") cholesterol

Tests that may be done to diagnose metabolic syndrome include:

  • Blood pressure measurement
  • Glucose test
  • HDL cholesterol level
  • LDL cholesterol level
  • Total cholesterol level
  • Triglyceride level

According to the American Heart Association and the National Heart, Lung, and Blood Institute, metabolic syndrome is present if you have three or more of the following:

  • Blood pressure equal to or higher than 130/85 mmHg
  • Blood sugar (glucose) equal to or higher than 100 mg/dL
  • Large waist circumference (length around the waist):
    • Men - 40 inches or more
    • Women - 35 inches or more
  • Low HDL cholesterol:
    • Men - under 40 mg/dL
    • Women - under 50 mg/dL
  • Triglycerides equal to or higher than 150 mg/dL

Preventing (and managing) the condition involves:

  • Eating a diet low in fat, with a variety of fruits, vegetables and whole-grain products
  • Getting regular exercise, at least 30 minutes of moderate activity almost every day
  • Losing weight so that your body mass index (BMI) is less than 25
  • Managing blood pressure and blood sugar
  • Not smoking
  • Trying to include fish, preferably oily fish, in your diet at least twice a week

Chronic Fatigue Syndrome is one of three conditions presumed by the federal VA to be service-connected for veterans of the 1991 Persian Gulf War. 

The abstract (summary) of the published study, Chronic fatigue syndrome is associated with metabolic syndrome: results from a case-control study in Georgia, is as follows:

Chronic fatigue syndrome is associated with metabolic syndrome: results from a case-control study in Georgia.

We hypothesized that persons with chronic fatigue syndrome (CFS) would have a higher prevalence of metabolic syndrome compared with well controls, and that unwell persons with insufficient symptoms or fatigue for CFS (termed ISF) would have a prevalence of metabolic syndrome intermediate between those with CFS and the controls.

We also sought to examine the relationship between metabolic syndrome and measures of functional impairment, fatigue, and other symptoms. Our analysis was based on a population-based case-control study conducted in metropolitan, urban, and rural areas of Georgia, United States, between September 2004 and July 2005. There were 111 persons with CFS, 259 with ISF, and 123 controls.

Metabolic syndrome was determined based on having at least 3 of 5 standard risk components (abdominal obesity, high triglycerides, high blood pressure, elevated fasting glucose, and decreased high-density lipids) according to the National Cholesterol Education Program Adult Treatment Panel III definition. Persons with CFS were 2-fold as likely to have metabolic syndrome (odds ratio = 2.12, confidence interval = 1.06, 4.23) compared with the controls.

There was a significant graded relationship between the number of metabolic syndrome factors and CFS; each additional factor was associated with a 37% increase in likelihood of having CFS. The association of ISF with metabolic syndrome was weaker (odds ratio = 1.72, confidence interval = 0.94-3.16). Among persons with CFS, the number of metabolic syndrome factors was significantly correlated with worse fatigue on a standardized summary measure of fatigue (r = 0.20, P = .04).

In conclusion, CFS was associated with metabolic syndrome, which further exacerbated fatigue. Published by Elsevier Inc.

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