Showing posts with label CFS. Show all posts
Showing posts with label CFS. Show all posts

Friday, December 10, 2010

Legislative Update: Current Status of DoD Gulf War Illness Research Funding Remains Volatile

 

Written by Anthony Hardie, 91outcomes.com

(91outcomes.com) – Just like last year, monitoring Congressional appropriations actions for the FY11 peer reviewed Gulf War Illness (GWI) research program administered under the Congressionally Directed Medical Research Program (CDMRP) and efforts to ensure the program’s funding success remain highly challenging. Gulf War Illness Program Booklet

As of today, it appears that both House and Senate actions suggest final GWI CDMRP funding for FY11 might be at $8 million, the same level as FY10. However, it should be noted that the situation continues to change rapidly. As always there are no guarantees until the entire Congress sends a final bill to the President.

Continued careful monitoring, combined with veterans advocates and organizations at the ready to contact key members of Congress, will be required.

House

On Wednesday, December 8, 2010, the House narrowly passed by a vote of 212-206 a Continuing Resolution (CR) that provides -- with various unrelated exceptions -- continued FY11 appropriations at FY10 levels, through September 30, 2011.

Under the CR, funding for the GWI program administered by the CDMRP reportedly would be retained at the FY10 funding level of $8 million.

Thirty-five House Democrats sided with 171 House Republicans in voting against the CR, while Eight Democrats and eight Republicans did not vote. This deep division suggests that future prospects for a final omnibus appropriations bill after Senate and conference action may also be challenging.

Senate

The Senate appropriations committee’s FY11 Defense appropriations act report language, which provides detailed funding by line item, directs $8 million for the Peer Reviewed Gulf War Illness Research Program.

The funding was requested in a letter by Senators Sanders, Bond, Feingold, Kerry, Tester, Schumer, Leahy, Durbin, Burris, Brown, Boxer, Snowe, and Kohl.

The Senate bill passed out of committee on September 16, 2010 by an 18-12 vote. Like all the other FY11 appropriations bills, the defense appropriations bill was not considered by the full Senate. However, it may very well remain a guide for future Senate action as discussed below.

Under the report accompanying the Senate bill, total appropriations for the military medical research programs currently operated by the CDMRP would be $358 million. In addition to the GWI appropriation, $150 million would be designated for peer reviewed research on breast cancer, $10 million for ovarian cancer, $80 million for prostate cancer, $60 million for psychological health and traumatic brain injury (TBI), and $50 million for the multifaceted peer reviewed medical research program (PRMRP).

FUTURE PROSPECTS

It is currently expected that the Senate will combine the House’s CR into a Senate omnibus appropriations bill. Any action must be completed by the end of the current Congress on January 3, 2011.

Additionally, the FY11 National Defense Authorization Act (NDAA) remains an unknown variable in the legislative equation. It remains unclear whether or not the NDAA will pass before the current Congress ends and what impact, if any, an enacted NDAA might have on the CDMRP’s GWI research program.

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Looking Back at Last Year: Who to Call

Last year, retaining funding for the Gulf War Illness research program was, as usual, extremely challenging for the handful of veterans advocates and organizations involved.

Initially, the Senate version of the FY10 Defense Appropriations Act lumped Gulf War Illness under the Peer Reviewed Medical Research Program (PRMRP), a catch-all that included more than two dozen conditions including GWI and funded at just $50 million. While the PRMRP restricts research to the listed conditions, there is no guarantee that research will be funded for any particular condition from among those listed.

Initially, the House failed to include funding for the GWI program at all.

However, as the bill went back and forth between the House and Senate, advocacy efforts resulted in amendments to the final bills in both chambers and final FY10 GWI funding at $8 million.

A last minute save on October 1, 2009 by Sen. Bernie Sanders (I-Vt.) and four of his colleagues amended (SA 2559) the Senate’s bill to include an amendment that would have appropriated $12 million for the GWI program. Those Senators included Robert Byrd (D-W.Va.), Russ Feingold (D-Wis.), Dick Durbin (D-Ill.), and Sherrod Brown (D-Oh.).

And, a December 11, 2009 letter by Rep. Dennis Kucinich (D-Oh.) and 25 other Members of Congress called for the conference committee to fund the CDMRP’s GWI research program at the Senate’s $12 million level.

Ultimately, the conference committee set final funding for the FY10 GWI program at the original, lower House level of $8 million. Both the House and Senate agreed and the final Defense funding bill was enacted by the President.

GWI research supporters Sanders, Durbin, and Brown remain in the Senate.

However, Byrd died on June 28, 2010 and is being succeeded by former West Virginia Governor Joe Manchin (D-W.Va.). Feingold was defeated in the November 2010 election and is being succeeded by Ron Johnson (R-Wis.), a Tea Party favorite.

GWI research funding supporters who signed onto the December 2010 Kucinich letter included the following. Of the 21 who remain in Congress, only four are Republicans, who will hold the majority in the House beginning January 3, 2011.  
  • Rep. Tammy Baldwin (D-Wis.)
  • Rep. Shelley Berkley (D-Nev.)
  • Rep. John Boccieri
  • Rep. Corrine Brown (D-Fla.)
  • Rep. Henry Brown, Veterans’ Affairs Health Subcommittee Ranking Member
  • Rep. Dan Burton (R-Ind.)
  • Rep. Steve Buyer, House Veterans’ Affairs Committee Ranking Member
  • Rep. John Conyers, Jr. (D-Mich.)
  • Rep. Bob Filner (D-Calif.), House Veterans’ Affairs Committee Chair
  • Rep. Charlie Gonzalez (D-Tex.)
  • Rep. Raul Grijalva (D-Ariz.)
  • Rep. Luis Gutierrez (D-Ill.)
  • Rep. John Hall
  • Rep. Rush Holt (D-N.J.)
  • Rep. Dennis Kucinich (D-Oh.)
  • Rep. Steve LaTourette (D-Oh.)
  • Rep. Frank LoBiondo (R-N.J.)
  • Rep. Jim McGovern (D-Mass.)
  • Rep. Michael Michaud (D-Maine), Veterans’ Affairs Health Subcommittee Chair
  • Rep. Gwen Moore (D-Wis.)
  • Rep. Collin Peterson (D-Minn.)
  • Rep. Mike Quigley (D-Ill.)
  • Rep. Janice Schakowsky (D-Ill.)
  • Rep. Patrick Tiberi (R-Oh.)
  • Rep. Timothy Walz (D-Minn.)
  • Rep. Don Young (R-Alaska)
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FY11 PRMPR

PRMPR research areas in the Senate bill would include the 32 conditions listed below. Four that are particularly relevant to Gulf War veterans are highlighted. The House CR would retain the list the same as in FY10. It should be noted that the final outcome remains indeterminate.
  1. amyotrophic lateral sclerosis (ALS),
  2. autism,
  3. blood cancer,
  4. chronic fatigue syndrome,
  5. chronic migraine and post-traumatic headache,
  6. dental research,
  7. drug abuse,
  8. epidermolysis bullosa,
  9. epilepsy,
  10. fragile x syndrome,
  11. inflammatory bowel disease,
  12. interstitial cystitis,
  13. kidney cancer,
  14. lupus,
  15. melanoma,
  16. mesothelioma,
  17. multiple sclerosis (MS),
  18. neuroblastoma,
  19. neurofibromatosis,
  20. osteoporosis and related bone disease,
  21. Paget's disease,
  22. pancreatitis,
  23. Parkinson's,
  24. pediatric cancer,
  25. pheochromocytoma,
  26. polycystic kidney disease,
  27. post-traumatic osteoarthritis,
  28. scleroderma,
  29. social work research,
  30. tinnitus,
  31. tuberous sclerosis complex, and
  32. vision research.
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SOURCES:

§ FY11 House Continuing Resolution (CR) for combined FY11 appropriations: H.R. 3082 [Would fund GWIRP at $8 million]

§ Senate FY11 Defense Appropriations Act, S. 3800 [Would fund GWIRP at $8 million]

§ Senate FY11 Defense Appropriations Act Committee Report, S. Rpt 111-295 [Would fund GWIRP at $8 million]

§ FY10 National Defense Authorization Act (NDAA), PL 111-84 [Authorized GWIRP at $12 million]

§ FY10 Defense Appropriations Act Explanatory Statement (essentially the conference report), p. 367 [Funded GWIRP at $8 million]

Wednesday, September 29, 2010

Fibromyalgia News

Editor’s Note:  Fibromyalgia, a neurological condition with chronic widespread pain and other multiple, chronic symptoms, is a presumptive condition for Gulf War veterans.

Some scientists believe that Gulf War Illness is unique from fibromyalgia.  However, even if the two conditions are separate, they do not disagree that they may be closely related and may benefit from some of the same or similar treatments.

Below are some of the most recent new articles by, for and about people suffering from fibromyalgia.

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The Fatigue in Fibromyalgia: Not 'Normal Tiredness'About - News & Issues.  The fatigue experienced in fibromyalgia goes beyond "normal tiredness," according to research just published in the journal BMC Musculoskeletal Disorders. ...

The gender gapBoston Globe.  Women suffer disproportionately from irritable bowel syndrome, fibromyalgia, headaches (especially migraines), pain caused by damage to the nervous system, ...
See all stories on this topic »

A Downside to Tai Chi? None That I SeeNew York Times.  The latest and perhaps best designed study was conducted among patients with debilitating fibromyalgia, a complex and poorly understood pain syndrome. ...
See all stories on this topic »

Yoga Can Ease the Chronic Pain of Fibromyalgia — You Web News .…  By youwb.  Fibromyalgia is a chronic pain disorder that affects up to 10 million Americans, most of them women. It was identified in 1816 by a Scottish physician, but wasn't officially recognized by the American Medical Association as an illness ...
You Web News youwb.com - http://www.youwb.com/

Denver Acupuncture Center: Treatments for Fibromyalgia.  Acupuncture is one of the many TCM or Traditional Chinese Medicine treatments that are known and have been proven to be an effective therapeutic method for.
ArticleSlash - Free Article Directory - http://www.articleslash.net/

Negative Emotions Increase PainMedPage Today.  In a cohort study among 121 women -- 62 of whom were diagnosed with fibromyalgia -- pain induced by an electrical stimulus was more keenly felt after the ...
See all stories on this topic

Anger and Sadness Increase Pain in Women With and Without FibromyalgiaArthritis Today.  By Jennifer Davis 9/28/10 Researchers who set out to understand the role emotions play in fibromyalgia pain may have ended up dispelling a myth – that women ...
See all stories on this topic »

Wrong & Right Gifts for Someone With Fibromyalgia & Chronic Fatigue SyndromeAbout.com: Health.  Have you ever gotten a gift that you couldn't use because of your fibromyalgia or chronic fatigue syndrome? I get these all the time -- mostly body washes ...
See all stories on this topic »

5 fibromyalgia pain relief tips | Chronic Pain Management.   codedergal.  Five chronic Pain Management Guidelines and Chronic Pain Management Information.
Chronic Pain Management - http://chronicpainmanagement.blognub.com/

Saturday, September 4, 2010

Chronic Fatigue: XMRV Virus and Anti-Retroviral Drugs

Chronic Fatigue is a common symptom in Gulf War Illness; Chronic Fatigue Syndrome is a “Presumptive” condition for Gulf War veterans

Written by Cinda Crawford

(HealthMatterShow.com) - As reported 8/31/10 in Retrovirology, researchers are seeing some success in having XMRV retrovirus react to HIV Anti-retroviral drugs for CFS. (Sorry if the link will not work. It seems to be functioning hit or miss from their end, but the information is included below. Keep reading.)

Do their conclusions mean you should spend money to get tested for XMRV right now? Probably not. Do they mean that you should consider taking anti-retroviral drugs? Truly, no. Their conclusions are not that well-defined. Not yet.

Even so… no one can walk in someone else’s shoes to feel their desperation or fading hope, but truly this seems like a premature action to me. I urge you to wait for science to catch up with the news and expectations. We will eventually have a clear picture of XMRV, but unless you want to chase every possible scenario out there, it is more prudent to wait.

(See the abstract below.)

Abstract (provisional)

Background
XMRV (xenotropic murine leukemia virus-related virus) is the first known example of an exogenous gammaretrovirus that can infect humans. A limited number of reports suggest that XMRV is intrinsically resistant to many of the antiretroviral drugs used to treat HIV-1 infection, but is sensitive to a small subset of these inhibitors. In the present study, we used a novel marker transfer assay to directly compare the antiviral drug sensitivities of XMRV and HIV-1 under identical conditions in the same host cell type.

Results
We extend the findings of previous studies by showing that, in addition to AZT and tenofovir, XMRV and HIV-1 are equally sensitive to AZddA (3′-azido-2′,3′-dideoxyadenosine), AZddG (3′-azido-2′,3′-dideoxyguanosine) and adefovir. These results indicate that specific 3′-azido or acyclic nucleoside analog inhibitors of HIV-1 reverse transcriptase (RT) also block XMRV infection with comparable efficacy in vitro. Our data confirm that XMRV is highly resistant to the non-nucleoside RT inhibitors nevirapine and efavirenz and to inhibitors of HIV-1 protease. In addition, we show that the integrase inhibitors raltegravir and elvitegravir are active against XMRV, with EC50 values in the nanomolar range.

Conclusions
Our analysis demonstrates that XMRV exhibits a distinct pattern of nucleoside analog susceptibility that correlates with the structure of the pseudosugar moiety and that XMRV is sensitive to a broader range of antiretroviral drugs than has previously been reported. We suggest that the divergent drug sensitivity profiles of XMRV and HIV-1 are partially explained by specific amino acid differences in their respective protease, RT and integrase sequences. Our data provide a basis for choosing specific antiretroviral drugs for clinical studies in XMRV-infected patients.

Best wishes for your speedy recovery from CFS, Chronic Fatigue Syndrome,
Cinda Crawford, host of the Health Matters Show

Tuesday, April 28, 2009

Ashok Gupta Explains the Amygdala Retraining Program for Gulf War Syndrome, ME/CFS/FM, and Associated Illnesses

by Ashok Gupta*
April 28, 2009

Ashok GuptaMedical researcher Ashok Gupta has raised much interest with his ‘Amygdala Hypothesis’ for ME/CFS/FM and associated illnesses, and the Amygdala Retraining™ techniques he believes have helped him and many others to 're-set' a chronic over-stimulation of the brain's unconscious alarm and protection responses. He says the techniques do offer hope of improvement or recovery now for many with these illnesses, and further medical research is required to develop supporting treatments.

Once you have reviewed the following information, Ashok Gupta invites you to submit questions here for his consideration in preparation for a future Live Chat Q&A in the ProHealth.com Community Chat Room.

____________________________

I have suffered from ‘chronic fatigue syndrome’ (ME/CFS) myself. Around 10 years ago, I developed it while studying at University.

Since then, I have dedicated my life to finding an effective treatment for ME/CFS and associated conditions such as fibromyalgia, multiple chemical sensitivities, Gulf War Syndrome, etc. I have been completely well for years, and I successfully treat patients at my clinic in Harley Street in Central London (www.guptaprogramme.com; e-mail: Info@guptaprogramme.com).

To help you understand the process that I believe has helped me and many others to improve, I will look at:

An overview of The Amygdala Hypothesis – a “vicious cycle” that, once triggered by severe stressors in people with certain risk factors can perpetuate neurological overstimulation, physiological dysfunction, and many physical symptoms.

An explanation of major symptoms in the context of this hypothesis.

A brief summary of Amygdala Retraining concepts - how patients may break the vicious cycle by applying techniques that encourage the amygdala and associated brain structures to discontinue the hypothesized overstimulation - and pilot results observed at one year.

Links to six free YouTube videos from the Retraining Program DVDs, which cover the entire hypothesis in depth.

THE AMYGDALA HYPOTHESIS

My medical research seems to indicate that ME/CFS is a neurological condition, and may be caused by abnormalities in a brain structure called the “amygdala,” which is deep in the unconscious brain.



One of the amygdala’s roles is to protect the body from potential threats.

• Research on the amygdala has traditionally focused on physiological or emotional threats,

• Whereas recent research is showing that the amygdala is involved in protection mechanisms related to chemical and immunological threats as well.

This hypothesis serves as a potential unifying model for the various observations in patients. I published my hypothesis in the peer reviewed journal Medical Hypotheses in 2002. (It is available to read online here: www.guptaprogramme.com/html/medicalPaper.asp )

Below, I will go through a basic explanation of the medical paper in layman’s terms using the following diagram:




PRECIPITATING FACTORS

Genetic and Environmental Risk Factors (1)
Right at the top, let’s start with the predisposing factors to developing these illnesses - i.e., the risk factors. These may include genetic factors and environmental factors yet to be fully determined.

Then there are two other precipitating factors which contribute to these illnesses developing in someone.

Triggers: Acute Psychological Stress (2) & Viral, Bacterial, or Other Triggers (3)
The start of the illness is often accompanied by psychological or physical stress, as well as some kind of acute physical illness.

• In the case of ME/CFS, that physical illness might be a particularly difficult virus or bacterial infection (e.g., Glandular Fever, gut enteroviruses, etc.), or another kind of illness.

• In fibromyalgia, the physical trauma may be an accident, or ongoing chronic pain in a part of the body.

• In MCS, the trigger may be heavy exposure to a toxin.

There will be crossovers in symptoms between these three conditions, according to the theory. The theory predicts that the pattern of symptoms in the body will be different, but that the underlying cause may be the same. The theory still holds if there is a gradual onset versus a specific onset (see medical paper for further details.)

Gulf War Syndrome may represent a combination of all three illnesses to varying degrees, as at the time there was exposure to immunizations, toxins, and physiological stresses all at the same time.

TRAUMA TO THE AMYGDALA

The combination of these precipitating factors changes the circuitry of the amygdala, making it continually over-stimulate the body (4).

During the trauma:

• The amygdala learns to be hyper-reactive to any symptoms detected in the body, in association with the “insula” (another brain structure).

• This conditioning happens unconsciously without a person actually realizing it is happening.

CHRONIC STIMULATION OF THE AROUSAL SYSTEM

From then on, the amygdala continually over-stimulates the sympathetic nervous system directly (5)

The sympathetic nervous system is the emergency response of the body to threats. When it is triggered, the parasympathetic nervous system (bodily repair, detoxification, digestion, etc.) is switched off and energy is diverted to the emergency.

• It over-stimulates the hypothalamus and the whole HPA (Hypothalamic-Pituitary- Adrenal) Axis, which subsequently downgrades as a result, making it difficult for the body to respond to stress.

• The amygdala also over-stimulates the whole brain, keeping many brain circuits in a state of hyper-arousal. This adversely affects the levels of neurotransmitters in the brain, including serotonin and dopamine.

• There may also be conditioning in the immune system. This means that aspects of the immune system are inappropriately re-triggered in a unique pattern individual to each patient.

• Finally, this over-stimulation causes higher levels of oxidative stress in the body, and a compromised immune system.

A continual unremitting stimulation can cause symptoms which can severely affect every single organ and system in the body, including the endocrine (hormonal) system, and the immune system. (See the Appendix detailing "How the Different ME/CFS/FMS Symptoms are Created with Continual Amygdala Stimulation.")

Furthermore, continual stimulation can cause secondary effects in the body, which then lead researchers to think that those physical observations are the cause of the condition, whereas they are simply symptoms of a deeper underlying brain abnormality.

SYMPTOMS AND SECONDARY ILLNESS CYCLES

Hyper-arousal of the body then causes the symptoms (6) and creates Secondary Illness Cycles (7).

Over-stimulation can cause adaptation in receptors so that systems are down-regulated, or certain systems may simply exhaust due to over-stimulation, as is the case with the adrenal glands. Nitric oxide levels may rise (as per the observations of Professor Martin Pall), which can cause a whole host of secondary effects and symptoms in the body, including mitochondria dysfunction, perpetuating the entire vicious circle. Because the immune system is responding inappropriately, opportunistic viruses such as HHV-6 have the opportunity to flourish, increasing symptoms.

Finally, at 7, secondary illnesses such as allergies and chemical sensitivities can occur due to the hypersensitivity of the entire system.

Where I differ from Professor Martin Pall’s Nitric Oxide hypothesis of ME/CFS and other “unexplained" illnesses is that in his NO/ONOO- hypothesis, the Nitric Oxide effects are mainly local.

• I do not believe that this could explain such a pervasive illness with such wide-ranging symptoms.

• Instead, I believe that the Nitric Oxide theory reflects yet another secondary illness cycle rather than the underlying cause of the condition.

Sympathetic over-activity means that sleep rhythms are affected, so the restorative “delta” sleep required for bodily repair is not effective. This has also been shown in Post Traumatic Stress Disorder, an illness where the amygdala has also been heavily implicated. This causes a patient to feel unrefreshed the next morning, causing severe exhaustion, and contributing to pain in fibromyalgia.

PERPETUATING FACTORS

These symptoms are detected by the sensory thalamus/cortex and the insula cortex - the parts of the brain that receive incoming information from the senses (8).

And to complete the cycle, incoming signals are magnified by the amygdala, which keeps the brain and nervous system in a state of hyper arousal. (9)

• The insula may be involved in interpreting the emotional meaning of the symptoms, and passing that representation on to the amygdala.

• At 9, the amygdala is traumatized by any symptoms that it detects in the body, and instantly re-stimulates bodily systems at 4 again.

Note that this central nervous system sensitivity (and resultant abnormal sensory processing causing heightened pain awareness) is gradually becoming a more accepted hypothetical model in fibromyalgia. This then perpetuates into the vicious circle as in the diagram.

FACTORS DETERMINING SYMPTOMS & SEVERITY

If the circle becomes particularly vicious, a patient can become bed-bound. If the cycle is milder, the patient may be able to function to a varying degree. The symptoms in each patient will depend on three factors:

• The severity of the conditioning effects in the amygdala and associated brain structures.

• The specificity of the conditioning; that is, what symptoms and what reactions were going on in the body at the time of the original trauma.

• The specific timing of the trauma – although symptoms can change over time.

Due to the secondary effects of the condition on the body, food intolerances can develop, as well as general sensitivities. This is because when the brain and body are on high alert, the amygdala (in association with other brain structures) is prone to learning new responses to stimuli it would not normally care about.

When the sympathetic system is aroused, digestive and detoxification systems are turned down or switched off, which may explain why many patients complain of feeling “toxic” inside.

A patient will also find that stress can exacerbate the symptoms - simply because it “speeds up” the vicious circle, and the body does not have sufficient resources to deal with that stress. The stress can be mental, emotional or physical.

With some patients, the conditioning effects are not particularly severe, which is why some patients seem to regain their health through general changes in lifestyle. For others, the conditioning in the brain is severe and causes chronic long term illness.

RETRAINING THE AMYGDALA – BASIC CONCEPTS

I wish to emphasize that I believe ME/CFS, fibromyalgia and MCS are real physical conditions, and are in no way psychological. The sensitivity conditioning mainly occurs unconsciously.

As I indicated above, Gulf War Syndrome may represent a combination of all three illnesses to varying degrees, as at the time there was exposure to immunizations, toxins, and physiological stresses all at the same time.

Currently, I do not believe that there are any pharmaceuticals which could target such a specific reaction in the brain. Most pharmaceuticals or supplements target the symptoms rather than the underlying cause. If the conditioning effects are mild, successful treatment of symptoms may bring full recovery, but in the majority of cases, this will probably not occur.

The unconscious brain reaction involved in amygdala dysfunction is not normally under a patient’s control, but I believe that some novel “brain retraining” techniques derived from NLP (Neuro-Linguistic Programming), breathing, meditation techniques, and others, can target the reaction and control the amygdala. The techniques are highly specialized, and do not fit under any one category, which is why I refer to them as "Amygdala Retraining Techniques."

Luckily the amygdala constantly communicates with other parts of the brain, and that’s where retraining can take place.

In animal models, it is understood that the amygdala can be controlled with new neurons being formed, connecting from the pre-frontal cortex to the amygdala, to subdue and control its reactions.

• Some studies have shown that patients with ME/CFS have lower grey matter volume in this part of the brain (pre-frontal cortex).

• Other studies have shown that regular meditation can increase the volume of this part of the brain, showing that “brain” exercises can alter the structure of the brain.

All the Amygdala Retraining techniques are now available as an interactive DVD recovery programme.** I found that most patients could not afford to come to the clinic for treatment, so I wanted to create something that was affordable and easy to use at home.

PILOT RESULTS TO DATE

I recently conducted an initial Clinical Audit on the techniques, and the study seems to show that over 90% of patients significantly improved as a result of the treatments, and that two-thirds of patients (67%) reached a full recovery or close to that mark within one year. The average number of years with the illness was 10.5 years.

This paper has been submitted for peer review and will be published in a medical journal later in 2009. There was no control group - as this was simply an initial pilot to stimulate funding for a larger randomized, controlled trial.

FREE VIDEOS DETAILING THE HYPOTHESIS

If you are interested in finding out more about the hypothesis, you can view videos online at YouTube which are taken from the home-study programme and cover the entire hypothesis in depth:

Session 2: PART 1
http://www.youtube.com/watch?v=SEtyMHbf08U

Session 2: PART 2
http://www.youtube.com/watch?v=OYuOXdjaSJY

Session 2: PART 3
http://www.youtube.com/watch?v=8GKA3h56VWc

Session 2: PART 4
http://www.youtube.com/watch?v=JU-rOvhTZxA

Session 2: PART 5
http://www.youtube.com/watch?v=1YhI9eXkTic

Session 2: PART 6
http://www.youtube.com/watch?v=01srRrDqj54


Finally, see the accompanying article, "How the Different ME/CFS/FMS Symptoms are Created with Continual Amygdala Stimulation," for an explanation of each physical, emotional, and cognitive symptom commonly associated with these and related illnesses.
___
* Ashok Gupta's Amygdala Retraining Clinic - Harley Street Solutions, LTD - is located at No.1 Harley Street, London W1G 9QD, UK. To contact the clinic, visit www.guptaprogramme.com or e-mail Info@guptaprogramme.com.

** Amygdala Retraining is available as a home study interactive DVD Recovery Programme, which includes DVDs, a CD, and a book, as well as access to a recovery forum and further support. The programme comes with a one-year money back guarantee. For further details, visit www.guptaprogramme.com.

Note: This information has not been evaluated by the FDA. It is for general information only, and is not meant to diagnose, prevent, treat or cure any illness, condition, or disease. It is very important that you make no change in your healthcare plan or health support regimen without researching and discussing it in collaboration with your professional healthcare team.