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Treatment of Memory Impairment and Sensorimotor Deficits in an Animal Model for the Gulf War Veterans' Illnesses
Posted November 17, 2011
Dr. Mohamed B. Abou Donia
Posted November 17, 2011
Dr. Mohamed B. Abou Donia

In the study, rats in the GW model, either Flupirtine-treated or untreated, are compared with Flupirtine-treated and untreated normal controls for performance in a water maze test. Rats are timed as they try to find a hidden platform in a water tank from different starting points. Reduced swimming times indicate spatial learning and memory. The water maze test also gauges sensorimotor parameters such as reflexes, motor strength, and coordination. In addition, researchers learn about cognition from observing the rats' probing activity during these tests. The study is currently underway, and data will be collected over the next 3 years. Dr. Abou Donia's GW exposures model has effectively reproduced GWI symptoms, as the rats developed alterations in memory and neuropathology. The effects of Flupirtine will be analyzed after all water maze and histopathological tests have been completed. If successful, this research would provide proof of concept that could ultimately lead to FDA approval of Flupirtine for the treatment of GWI.
1 comment:
I hope this drug trial is beneficial. When its time for clinical trials on humans please let me know where to sign up!!
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