Thursday, March 1, 2018

University of South Carolina researcher given grant to advance treatment and understanding of relationship between gut-microbiome and Gulf War Illness

SOURCE:  University of South Carolina, Arnold School of Public Health, March 1, 2018



Arnold School’s Saurabh Chatterjee secures a nearly $1 million grant to advance treatment and understanding of relationship between gut-microbiome and Gulf War Illness

March 1, 2018 | Erin Bluvas, 
Saurabh Chatterjee, associate professor of environmental health sciences, will lead a research project that aims to further scientists’ understanding of the connection between the gut microbiome and Gulf War Illness (GWI) and advance related treatment options. Characterized by symptoms such as chronic headache, cognitive difficulties, respiratory problems, sleep problems, gastrointestinal problems, and other unexplained medical abnormalities, there is increasing evidence that GWI is caused by environmental chemical exposure and preventive drugs taken by soldiers during deployment. The condition continues to affect 25-32 percent of the 700,000 U.S. veterans who served in the 1990-1991 Persian Gulf War.
“In spite of a long span of 25 years since the war ended, veterans continue to suffer from a series of chronic multi-symptom illnesses that consist of chronic fatigue, post-traumatic stress, chronic pain, neurological abnormalities, gastrointestinal disturbances and metabolic alterations,” says Chatterjee. “From our recent studies, we now know that the diverse bacteria within the gut may be a key to unlocking the cause of the gulf war illness that continues to plague our veterans.”
With funding support from the Department of Defense Congressionally Directed Medical Research Program, Chatterjee and a group of researchers* from around the country will use the three-year grant to learn how to best treat patients with GWI. Working both in the lab and with Gulf War veterans, the researchers will further explore the relationship between the gut-microbiome and GWI symptom persistence and disease development. They will also investigate effective treatment options, such as probiotics, to help alleviate symptoms and improve quality of life for soldiers and veterans.
The project builds on a pilot study conducted in Chatterjee’s Environmental Health and Disease Laboratory, where his team of scientists were the first to discover a link between the gastrointestinal disturbance (e.g., bloating, flatulence, indigestion) of GWI with changes in the intestinal microbiota. This foundational research also laid the groundwork for new treatment options, such as using probiotics to rebalance the gut-microbiome and prevent the transfer of harmful byproducts to the rest of the body.
Previous studies have focused on neurological abnormalities (e.g., impairments to cognition, memory, and learning) associated with GWI. In addition to limiting their scope to neurological effects cause by GWI, these studies were also unable to uncover the pathways through which GWI affects the brain.
“If successful, this project will have tremendous impact by finding a novel mechanistic pathway for gulf war illness and a novel treatment strategy that can be implemented immediately,” says Chatterjee. “Moreover, the identification of microbial alterations in Gulf War veterans and the effectiveness of an FDA-approved probiotic therapeutic strategy will pave the way for a personalized medicine approach that is novel, inexpensive and timely.”
*Investigators include Saurabh Chatterjee (University of South Carolina, Principal Investigator), Kimberly Sullivan (Boston University), Nancy Klimas (Nova Southeastern University), Stephen Lasley (University of Illinois), Ronnie Horner (University of South Carolina), Ratanesh Seth (University of South Carolina), M.B. Abou-Donia (Duke University), and Patricia Janulewicz (Boston University, Co-PI).

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